Which department should handle the loss of hotel items?

That depends on how many star hotels you are. High-star hotels are handled by the unit security department. Valuables involved in legal disputes shall be handed over to the local public security organ by the security office, which shall assist the public security organ in handling them together. If it is a guest house or budget hotel below Samsung, there is generally no formal professional security department, and most security practitioners have not received professional security training. Let them handle it. They can't handle it. Generally handled by a department manager or vice president in the store.