What does Bao mean in medicine?

Security is an examination, and the principle of determination is the determination of gastric acid secretion. Determination of gastric basic gastric acid secretion (BAO) refers to gastric acid secretion for several hours without food or drug stimulation.

There are many methods to check gastric acid secretion in clinic: observing gastric juice secretion function without any stimulus, such as basic gastric acid secretion test. Stimulate gastric mucosal secretory cells directly or indirectly and observe their secretory function, such as pentagastrin test. There is also the observation of gastric secretion function through vagus nerve stimulation, such as insulin stimulation gastric secretion test, which is selected according to clinical needs.

Normal value of gastric basic gastric acid secretion (BAO):

The volume of basal gastric juice 10 ~ 100 ml, Bao 3.9 1.98 mmol/h, and pH 0.8 ~ 1.8.

Clinical significance of determination of gastric basal gastric acid secretion;

Abnormal results: BAO and PAO increased in duodenal ulcer and compound ulcer, with BAO > 0.05；; 5mmol/h has diagnostic significance; If pao > 40 mmol/h, it indicates that bleeding or perforation will occur. BAO and PAO decreased significantly after duodenal ulcer operation, and also decreased significantly after subtotal gastrectomy. If anastomotic ulcer occurs after operation, it will increase gradually. The Ph > value of gastric acid secretion test of pentagastrin; 7 is true gastric acid deficiency; If the pH value is between 3.5 and 7.0, it is hypochlorous acid; Severe cases of gastric cancer and atrophic gastritis can be manifested as real gastric acid deficiency. Zhuoai syndrome (gastrinoma) Bao >; 15mmoL/h, gross & gt30mmol/h, and the ratio of BAO/MAO, often >: 0.6, so the pentapeptide gastrin test has been used as a diagnostic basis.

People who need to be examined: people with hyperacidity, hypoacidity, intestinal diseases, etc.

Extended data:

Reagent for determination of gastric acid secretion:

(1)0. 1 mol/liter sodium hydroxide solution.

(2)0.2g/L phenol red indicator, 100mg phenol red, 28.2ml 0. 1mol/L NaOH solution, dissolve it and add water to 500ml.

Operation method: Take 5ml of 5 gastric juices respectively, and add 2 drops of phenol red indicator. Yellow indicates the presence of stomach acid. Titrate it to pink with 0. 1mol/L NaOH, and multiply the number of milliliters of NaOH-removed solution by 20 to obtain the concentration of gastric acid (mmol/L).

Precautions:

(1) guarantee: 24 hours before the test, all drugs that can affect the secretion of gastric juice were used, and fasting12 hours. Then the gastric juice on an empty stomach in the morning is pumped out and discarded, and all the gastric juice in 1h is continuously collected, and the amount is recorded in a vial for inspection.

(2) After abalone samples were taken, gastrin pentapeptide was injected into the hair muscle, and the dosage was calculated as 6μg/kg body weight. A sample was collected every 15min, and sent to four bottles with partial numbers for inspection.

(3) In recent years, some scholars argue that the ratio of basal gastric juice secretion to peak gastric juice secretion in normal people should be lower than 0.20, and in some cases it can be as high as 0.302. If it exceeds 0.6, we should consider gastrinoma.

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