Instructions for patients with Xuanyunning

Administration and dosage: Take orally, 2-3 tablets at a time, 3-4 times a day.

Specification 18 a pack of 24 packs

Mechanism of action

Sanjinbai Xuanyunning is a pure Chinese medicine preparation, which is extracted from Alisma Decoction in Synopsis of the Golden Chamber in the Han Dynasty, Erchen Decoction in Taiping Huimin Hejiju Prescription in the Song Dynasty and Erzhi Pill in Zheng Zhi Standard in the Ming Dynasty on the basis of exploring the experience of treating vertigo with ancient prescriptions and proven prescriptions.

Sanjinbai Xuanyunning has a definite and stable curative effect on vertigo, is safe and has no toxic and side effects, and has a good therapeutic and preventive effect on vertigo caused by various reasons.

⑴ Indications for vertigo: Xuanyunning contains Ligustrum lucidum, Eclipta prostrata and Achyranthes bidentata, all of which can treat liver and kidney, replenish yin essence of liver and kidney, make the essence sufficient, clear the orifices and nourish; Chrysanthemum is used to clear liver and purge fire, help liver yin and control hyperactivity of liver yang. On the other hand, Atractylodes macrocephala, Poria cocos and Glycyrrhiza uralensis can not only enhance the function of ascending and descending middle energizer, but also eliminate phlegm-dampness and turbid qi by enhancing the function of transporting spleen and stomach. In addition, tangerine peel, Pinellia ternata and Alisma orientalis are added to promote diuresis and eliminate phlegm, regulate qi and eliminate phlegm, and can remove phlegm, promote middle warmer and clear qi, nourish qi and clear orifices. Turbid gas drops, the clarity is not blind, and dizziness is naturally controlled.

⑵ Improve related symptoms: Xuanyunning can not only treat vertigo itself, but also treat a series of symptoms related to vertigo. "Xuanyunning" can relieve tinnitus by benefiting liver and tonifying kidney. Through the function of reducing adverse flow and stopping vomiting, symptoms such as nausea, vomiting, foaming and abdominal distension can be eliminated.

Product characteristics

It takes effect quickly, and dizziness can be relieved in most cases after taking the medicine for 3-5 times, and the symptoms disappear in 5-7 days, especially for patients with vertigo attack and serious illness.

Stabilizing effect. It has a good sedative effect, which is different from ordinary sedative hypnotics. Even if it is close to toxic dose, it still does not show hypnotic effect.

It has a good effect on the central transmitter. Xuanyunning can increase the contents of NE (norepinephrine), DA (dopamine) and 5-HT(5- hydroxytryptamine) in brain tissue. These central transmitters are closely related to maintaining normal spirit, mood and sleep, and they complement each other, making the regulation function of the central nervous system more perfect.

It can regulate blood pressure in two directions, reduce hypertension and increase hypotension.

Relieve intestinal smooth muscle spasm. Eliminate symptoms of autonomic nervous dysfunction related to vertigo, such as nausea and vomiting.

Anti-inflammatory and detumescence effects. Eliminate inflammation of vestibular organs that can lead to dizziness.

It is safe to take and has no toxic or side effects in clinical observation.

At present, there are many Chinese and western medicines that can treat vertigo at the same time on the market, but the drugs specially used for treating and preventing vertigo are extremely rare. Sanjinban Xuanyunning brings good news to all kinds of vertigo patients.

Analysis of Xuanyunning Prescription

Xuanyunning is a combination of Alisma Decoction in the Synopsis of the Golden Chamber in the Han Dynasty, Erchen Decoction in the Prescription of Taiping Huimin Mixture in the Song Dynasty and Erzhi Pill in the Zheng Zhi Standard in the Ming Dynasty on the basis of summarizing the expositions of doctors in previous dynasties on vertigo.

This prescription is mainly used for dizziness caused by phlegm-dampness and blood stasis and deficiency of liver and kidney. In the prescription, Atractylodes macrocephala has the functions of invigorating spleen and qi, eliminating dampness and resolving phlegm, and spleen is the source of phlegm. When the spleen and stomach are healthy, water and dampness are transported normally, and there is no worry about wet phlegm. The source of phlegm can be eliminated and dizziness can be stopped. It is the main medicine. Poria, spleen strengthening, dampness eliminating and Zhonghua Yin are commonly used drugs for treating phlegm. Alisma orientalis promotes diuresis, and Poria cocos promotes Alisma orientalis, and its diuresis effect can be doubled; Alisma orientalis has poria cocos, which benefits water without hurting temper, and the two drugs complement each other; Pinellia ternata can eliminate dampness and phlegm, regulate stomach, reduce adverse flow and stop vomiting; Chenpi regulates qi and strengthens the spleen, and eliminates dampness and phlegm; The combination of the four herbs enhances the functions of strengthening spleen and benefiting qi, eliminating dampness and resolving phlegm of Atractylodes macrocephala. Kidney stores essence and produces marrow, "the brain is the sea of marrow". Deficiency of kidney essence can not produce marrow and nourish brain, and deficiency of brain can cause dizziness and tinnitus. Therefore, the prescription is supplemented with Ligustrum lucidum, which nourishes kidney water, nourishes liver yin and benefits essence and blood; Eclipta prostrata nourishes yin and kidney; The combination of the two drugs can supplement yin deficiency of liver and kidney and deficiency of essence and blood. Long-term stagnation of phlegm, which turns into fire, causes liver wind to move internally and liver yang to rise, so there are symptoms such as dizziness, head swelling, headache, redness, bitter taste and pulse, and kidney yin deficiency, and water does not contain wood, which can also cause liver yang to rise. Therefore, adding chrysanthemum to the prescription is helpful to dispel cold and benefit yin, and has the functions of calming liver and suppressing yang, nourishing liver and kidney, benefiting yin and improving eyesight; Achyranthes bidentata can tonify liver and kidney, and is good at reducing adverse reactions. It is suitable for dizziness caused by liver and kidney deficiency and hyperactivity of liver yang, and can be compatible with chrysanthemum. The combination of the above four drugs can nourish the kidney and calm the liver, and can be used as an auxiliary treatment for dizziness caused by phlegm-dampness blocking collaterals and deficiency of liver and kidney. Glycyrrhiza uralensis Fisch in the prescription can not only strengthen the spleen and replenish qi, eliminate dampness and eliminate phlegm, but also reconcile various drugs, so it is an adjuvant medicine. The combination of the above medicines can play a role in invigorating spleen, promoting diuresis, benefiting liver and tonifying kidney.

Modern research on Xuanyunning

Atractylodes macrocephala contains volatile oil, atractyl alcohol and atractylone, which can enhance immunity. Poria cocos contains β-pachyman, which has diuretic and immune function. Alisma orientalis contains alisol, etc. Has the effects of reducing blood lipid, protecting liver and promoting diuresis; Pinellia ternata contains alkaloids, which can inhibit vomiting. Pericarpium Citri Tangerinae contains volatile oil and hesperidin, which has spasmolytic, liver-protecting and cholagogic effects. Ligustrum lucidum contains oleanolic acid, D- mannitol, linoleic acid and so on. Has antibacterial, anti-inflammatory, immune function enhancing, heart strengthening, nourishing and laxative effects. Chrysanthemum contains volatile oil, which has antibacterial, anti-inflammatory and antipyretic effects; Achyranthes bidentata contains saponins and steroids, and has anti-inflammatory, diuretic and antihypertensive effects. Glycyrrhiza uralensis Fisch contains liquiritin and glycyrrhetinic acid, which has anti-inflammatory, expectorant, bacteriostatic and adrenocortical effects. The whole prescription mainly has the functions of lowering blood pressure, reducing blood lipid, anti-inflammatory, antipyretic, spasmolytic, diuretic and enhancing immune function.

Xuanyunning adapts to the crowd.

Patients over 40 years old suffering from dizziness and vertigo caused by various diseases.

Indications of Xuanyunning

(1) TCM: phlegm-dampness blocking collaterals and dizziness caused by liver and kidney deficiency.

(2) Western medicine: ear vertigo: such as Meniere's disease, labyrinthitis, inner ear drug poisoning, positional vertigo, motion sickness, etc. Cerebral vertigo: such as cerebral atherosclerosis; Vertigo caused by other reasons: such as hypertension, hypotension, hyperviscosity, anemia, neurosis, cervical spondylosis, ocular vertigo, etc.

⑶ Symptoms: dizziness, dizziness, tinnitus, nausea, vomiting, headache, insomnia, palpitation and chest tightness.

Study on Pharmacology and Pharmacodynamics of Yunyunning

1, enhance inner ear microcirculation and promote vestibular function recovery. Xuanyunning can improve the blood supply of the left inner ear artery, increase the blood flow of the inner ear, restore the vestibular function and improve the blood supply of the inner ear by strengthening the local regulation of the microcirculation of the inner ear. Xuanyunning can obviously increase the synapses of labyrinthine nerve endings, increase synaptic vesicles and promote nerve repair.

2. Improve microcirculation and increase cerebral blood flow. Xuanyunning significantly increased the blood flow of left and right vertebral arteries and basilar arteries, and its effect was better than flunarizine.

3. Adjust blood pressure. Xuanyunning can effectively reduce the blood pressure of SHR rats after a single dose, and it can continue to significantly reduce the blood pressure of SHR rats after multiple doses. Its antihypertensive effect is slow, but it lasts for a long time. Xuanyunning can effectively reduce the blood pressure of rats with renal hypertension, and its hypotensive effect is through reducing angiotensin ⅱ.

4, improve the role of sleep. Xuanyunning can increase the contents of norepinephrine, dopamine and 5- hydroxytryptamine in the brain of rats, which are closely related to maintaining normal spirit, mood and sleep.

5. Relieve the spasm of intestinal smooth muscle. Xuanyunning has obvious antagonistic effect on intestinal muscle spasm caused by antispasmodic drugs in rats. Yunyunning can relax the contraction of intestinal smooth muscle, especially in the spasmodic contraction of intestinal muscle.

6. Anti-inflammatory effect. Xuanyunning has anti-inflammatory effect, and continuous gastric perfusion for 8 days can inhibit the development of thymus in mice.

Study on the Safety of Xuanyunning 'an

Determination of (1)LD50 According to the simplified probability method, the LD50 of mice was 48L 48g/kg (P = 0.95). Ld50 = 160 10g/kg was measured by Kohler's method (Sun Shi's improved method).

(2) In the subacute toxicity test, rats were given 62g/kg (equivalent to 200 times of adult oral dose) and 3lg/kg (equivalent to 100 times of adult oral dose) for 20 days. In the high dose group, individual animals can see loose hair, loose feces, reduced food intake and weight loss at the later stage of administration. The total number of red blood cells and white blood cells in high dose group was higher than that in control group (P

Summary of clinical research on Xuanyunning

Studies in 9 hospitals, including Guangxi People's Hospital, the First Affiliated Hospital of Guangxi College of Traditional Chinese Medicine, Guangxi Nanxishan Hospital, the Affiliated Hospital of Guilin Medical College, the Third Affiliated Hospital of Guangdong Zhongshan Medical College, the People's Hospital of Guilin, the Affiliated Hospital of Capital Medical University, the General Hospital of the People's Liberation Army, and the Guilin Hospital of Traditional Chinese Medicine, show that Halo Ning has the following functions:

The total effective rate of 1 and Xuanyunning group was significantly higher than that of vitamin B 1 group. The results show that vertigo can effectively promote the recovery of vestibular neurons.

2. Vertebrobasilar blood flow velocity measurement in two groups: 33 cases in Xuanyunning group, 6 cases were cured, 65,438+05 cases were markedly effective, 65,438+00 cases were effective and 2 cases were ineffective, with a total effective rate of 93.9%; In the control group, 3 cases were cured, the effective rate was 12 cases, the effective rate was 10 cases, and 8 cases were ineffective. The total effective rate was 75.8%. The total effective rate of Xuanyunning group was significantly higher than that of Sibelium group (P

Comparison of hemorheology and blood lipid between the two groups before and after treatment: Xuanyunning significantly reduced the specific viscosity of whole blood (P < 0.05) and plasma (P

The results show that Xuanyunning can effectively improve the blood flow of vertebrobasilar artery, improve cerebral circulation, reduce blood lipid and improve microcirculation.

3. Xuanyunning can effectively reduce systolic and diastolic blood pressure in patients with grade 2 hypertension (P

4. After the treatment of Xuanyunning, the clinical symptoms and signs of patients were obviously improved, and the difference was statistically significant. The results show that vertigo is better than that caused by cervical spondylosis.

To sum up, Xuanyunning 1 is particularly effective in treating vertigo attacks and severe patients. 2. Effectively increase the blood flow of vertebral artery and basilar artery, and increase the blood flow of inner ear. 3. It can regulate blood pressure in two directions, reduce hypertension and increase hypotension. 4, the effect is quick, dizziness can be relieved in most cases after taking the medicine for 3 to 5 times, and the symptoms disappear in 5 to 7 days. 5. It can effectively regulate blood viscosity, reduce blood lipid and improve microcirculation. 6. It is very safe to take and has no obvious toxic and side effects.