What about fetal cerebellar dysplasia?

There are many reasons for fetal cerebellar hypoplasia, the most important of which is congenital inheritance. If fetal cerebellar hypoplasia is possible, it will lead to fetal disability, because most actions of controlling people are in the cerebellum, and balance and stability come from the operation of the cerebellum. So, what about fetal cerebellar dysplasia?

What about fetal cerebellar dysplasia? If you check it, it will be more serious. The common reason is abnormal brain development in embryo or fetal brain development caused by mother's illness during pregnancy, so it is not necessary to deal with it temporarily. It is recommended to review the B-ultrasound. If the abnormality occurs again, it should be considered that it is related to the congenital dysplasia of the fetus and the pregnancy needs to be terminated.

Fetal infection with canine herpesvirus is the most common cause. Unknown congenital anatomical malformation of central nervous system. It was once thought to be related to genetic factors, but now it has been denied.

The symptoms caused by cerebellar dysfunction are the most obvious. The head, trunk and limbs lose their coordinated movements, the movements are out of balance, the head trembles, the body often swings, it is difficult to maintain normal posture, it is difficult to maintain standing balance (usually leaning to one side or back, sometimes leaning to the front and rolling), and nodding movement (caused by uncoordinated flexion and extension of neck muscles). Circumferential movement, spasm, nystagmus, inverted angle arch, limbs standing apart, scissor-like gait, abnormal limb movement, muscle weakness and other symptoms are also common. These symptoms can exist after birth, but it is difficult to distinguish them from normal dog movements at this time. So generally speaking, when puppies can walk normally (3~4 weeks after birth), the symptoms begin to be obvious.

The diagnosis and treatment of fetal cerebellar hypoplasia should be differentiated from head trauma, hydrocephalus and spinal cord defect in newborn puppies, but the disease should be suspected first when puppies start walking. Visually, dogs with cerebellar hypoplasia can see the collapse of posterior cranial fossa on lateral X-ray photography of the head. But this feature is not always visible. In addition, the severity of the disease is not necessarily parallel to the size of the cerebellum. At autopsy, there were different degrees of cerebellar atrophy (normal size of brain and medulla oblongata) with naked eyes. Histologically, there are characteristic manifestations (molecular layer cells, Purkinje cells and granular layer cells in cerebellar cortex are obviously reduced or even disappeared), so diagnosis can be made. Virus was isolated from cerebellum, and virus antigen was detected by fluorescent antibody method (mainly in Purkinje cells). High titer of virus neutralizing antibody in blood was also helpful to the diagnosis of diseases. Brain pacemakers can be installed to treat this disease. For patients with mild illness, exercise inhibitors sometimes work.