What substance is D2R?

supplement

Comparative study on dopamine transporter and dopamine D2 receptor imaging in striatum of monkey model of Parkinson's disease

China Journal of Neurology Volume 33 No.4, 2000

Objective To observe the functional changes of dopamine transporter (DAT) and dopamine D2 receptor (D2R) in striatum of unilateral Parkinson's disease (PD) monkey model, and to explore the clinical significance of DAT and D2R in the diagnosis of PD. Methods DAT ligand 99mTc-TRODAT- 12β-N, N- bis (2- thioethyl) ethylenediamine, 3β-(4- chlorophenyl) tropine and D2R ligand 13 1I-IBZM,/kloc-0 were used. The functional changes of DAT and D2R in striatum of monkey model of unilateral Parkinson's disease prepared by MPTP were observed by single photon emission tomography, and autoradiography of 13 1I-IBZM levo -2- hydroxy -6- methoxy -N-( 1- ethyl -2- pyrrolidine) methylbenzamide was performed. The concentrations of dopamine and its metabolites in rat tail, putamen and substantia nigra in vitro were detected by high performance liquid chromatography-electrochemical method. Pathological changes of substantia nigra striatum were observed by HE staining. Results DAT SPECT imaging showed that 99mTc-TRODAT- 1 radioactivity concentration was absent in the damaged striatum of MPTP in unilateral PD monkey model, while D2R SPECT imaging showed that 13 1I-IBZM and1I-AIB were found in the damaged striatum and MPTP intact striatum. Autoradiography further confirmed the results of D2R SPECT imaging. Biochemical and pathological changes confirmed that the model monkey was successfully prepared, which was consistent with the results of DAT SPECT imaging. Conclusion DAT changes in striatum of unilateral Parkinson's disease monkey model are earlier than D2R, and DAT SPECT imaging is helpful for early diagnosis and disease monitoring of Parkinson's disease.

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