Is it good for liver disease to do more exercise? What are the benefits?

comprehensive conditioning can fully protect the liver.

1. What do you know about diet conditioning? Diet should be diversified. Hepatitis patients don't have to emphasize taboos, and the diet principle is light, digestible and nutritious. Protein is an important material foundation of human body and the "raw material" of immune substances. Eating some eggs, milk, soybean milk, lean meat and fish soup properly is beneficial to the repair, growth and renewal of damaged liver cells, which can shorten the course of disease and reduce the probability of chronic hepatitis. At the same time, we should eat more vegetables, especially green leafy vegetables, and pay attention to maintaining weight to prevent fatty liver due to obesity. Hepatitis patients should pay special attention not to eat too much sugar, because the three major metabolism of human body mainly depend on the liver. If you take a lot of sugar after suffering from liver disease, it will inevitably increase the burden on the liver and induce diabetes. In addition, after you get hepatitis, you should ban alcohol, don't drink alcoholic beverages, and avoid taking drugs that damage the liver. For some common diseases, such as colds and coughs, it is appropriate to take Chinese herbal medicines or Chinese patent medicines.

2. It is also important to control emotions: patients with hepatitis should pay attention to maintaining optimism. Traditional Chinese medicine believes that the seven emotions of "happiness, anger, worry, thinking, sadness, fear and surprise" are different emotional reactions of the human body to external objective things, and as long as they are regulated normally, they will not lead to diseases. If there is strong or long-term seven-emotion stimulation, it will disturb the normal physiological activities of human body, make the function of viscera and qi and blood disorder, and lead to the occurrence or aggravation of diseases. Because "the liver governs anger", patients with liver disease are more irritable, while patients with chronic hepatitis B are suffering from long-term illness, mental stress and unstable mood. Therefore, we should pay special attention to maintaining a good attitude and not worrying too much about the harm of the disease itself, otherwise moping all day will affect sleep and appetite, and even aggravate the condition. In a word, a good mood is very important for the recovery of hepatitis patients.

3. moderate exercise should be kept in mind: generally speaking, patients with hepatitis a or hepatitis e who have been cured for more than half a year can participate in strenuous activities. However, patients with hepatitis B can't be considered as cured even if their symptoms disappear and their liver function is normal. Only after the surface antigen of hepatitis B turns negative can they be completely cured. At this time, we should also pay attention to the amount of activity. Intense activities such as playing ball games and participating in sports competitions should be avoided as far as possible. Those who have not changed after more than two years of follow-up can only exercise like normal people. In the acute stage of hepatitis and the active stage of chronic hepatitis, reducing physical exertion, reducing liver load and increasing liver blood flow are the key to treatment. In the recovery period, the rest principle is: combination of motion and static, proper exercise. Such as outdoor walking, sunbathing and Tai Ji Chuan. The amount of exercise should be gradually increased, so as not to be tired. Patients should rest for more than 1 hours every day, and stay in bed for half an hour to one hour after meals in principle.

in short, adhering to the above principles will definitely improve the quality of life of patients with hepatitis B.

The goals of effective treatment are: ① inhibiting virus replication and eliminating virus; ② Relieve symptoms; ③ Relieve inflammation and improve liver function; ④ Prevention of progression to cirrhosis and hepatocellular carcinoma; ⑤ Improve the survival rate of patients. At present, there are many methods to treat chronic hepatitis B, including antiviral drugs, immunomodulation, cytokines, anti-fibrosis, antisense oligonucleotides, ribozymes and so on. The definition of effective treatment is that HBV DNA is permanently removed from blood by non-PCR technology, HBeAg turns negative, anti-HBe appears, and ALT value drops to normal. When an infection changes from a replication phase to an integration phase, it usually ends in remission rather than cure. In the United States, interferon and lamivudine are the only drugs approved for the treatment of hepatitis B.

A recent meta-analysis of 15 studies on interferon evaluated the efficacy of interferon. Compared with untreated control group, the negative conversion rate of HBsAg was 6% higher and that of HBeAg was 21% higher. The negative conversion rate of HBV DNA was 2% (the detection threshold was 1.5 ~ 3. pg /ml or 5 ~ 1 million copies/ml). If PCR is used, the negative conversion rate of HBV DNA will decrease. Interferon 5MU or 1MU daily, three times a week or once every other day is a better treatment. The predictor of effective treatment is low viral load before treatment (HBV DNA <: 1pg/ml or <: 33 million copies /ml), high ALT (more than 3 times the normal upper limit), active necrotizing inflammation in the liver (including cytoplasmic HBcAg positive) and HIV negative.

high-dose interferon is more effective than low-dose interferon, but its side effects also increase. Treatment for 6 months is no more effective than that for 3 months, although the HBsAg negative conversion rate is significantly increased after interferon treatment for 4 or 6 months. The curative effect of women is better than that of men, and the effective rate of China patients is lower. Among the patients with liver cirrhosis, the patients with serious illness (Child－Pugh B or C) have poor curative effect.

Nucleosides and nucleotide analogues include lamivudine, famciclovir, adefovir, dipivoxil and lobacavir. They can inhibit HBV DNA replication. In a large-scale, randomized, controlled clinical trial, patients took lamivudine 1mg/ day orally for 12 months, and 16% ~ 32% of patients turned negative for HBeAg, and HBV DNA decreased to <: 1.5pg/ml or <: 5, copies /ml, while the effective rate of the control group was only 6%. The liver histology of most patients has improved. 6 ~ 18 months' lasting effective rate >: 8％。 Such as prolonging the treatment time of lamivudine (> 6 months), 15% ~ 3% of patients have mutations in HBV YMDD site, which leads to the decline of lamivudine efficacy. The best predictor of lamivudine is that the baseline ALT level is twice higher than the upper limit of normal value, while the curative effect of patients with normal ALT is not better than that of the control group. HBV DNA level is not a predictor of HBeAg negative conversion, and it is more likely to be effective if the patient's HBV DNA drops below 1 thousand copies /ml within 2 weeks of treatment. The best dose is 1mg/ day. Although the larger dose (3mg/ day) can make HBV DNA decrease faster, after 3 ~ 6 months of treatment, the clearance rate of HBV DNA is similar to the negative conversion rate of HBeAg. An Asian study shows that extending the course of lamivudine to three years can increase the negative conversion rate of HBeAg to 65%.

combination therapy in some recent studies, interferon (1MU) was given three times a week for 16 weeks, and gamasidine was given 1mg a day for 24 weeks, with an effective rate of 29%. In contrast, the effective rate of single drug is 18% ~ 19%, but the difference is not statistically significant.

antisense oligodeoxynucleotides and ribozyme antisense oligodeoxynucleotides block gene expression by hybridizing between the antisense and antisense strands of HBV DNA. In a recent study, antisense oligodeoxynucleotides inhibited the replication and gene expression of DHBV in Pekin ducks for a long time. Ribozymes represent another molecular mechanism to inhibit virus replication. They are antisense oligodeoxynucleotide catalysts, which can cleave RNA at specific sites.

The clinical outcome of immunomodulated acute HBV infection depends on the quality and intensity of the host's antiviral response. To be exact, HBV in infected hepatocytes may be eliminated by cytotoxic T lymphocytes (CTL), and its possible mechanisms are as follows: ① antigen activation CTL directly kills HBV and leads to the destruction of infected hepatocytes; ② Cytokines secreted by ②CTL (IFN-γ and TNF-α) can eliminate HBV by non-cytolysis, which leads to virus destruction (not destroying hepatocytes), and can eliminate HBV in a large number of hepatocytes by inhibiting virus replication and gene expression. Tolerance is virus-specific rather than universal immunosuppression. Many experimental studies suggest that CD8＋+and MHC type ⅰ CTL can clear the virus from infected cells. Therefore, T cell HBeAg epitope vaccine can be used to treat chronic HBV infection.

thymosin α-1 can increase the levels of endogenous IFN-α and γ, and also increase IL-2. It can also increase the expression of IL-2 receptor and enhance the proliferation and activity of CD3, CD4, CD8 and NK cells. In duck hepatocytes infected with HBV, thymosin α-1 seems to reduce virus replication, especially at the level of virus protein expression. It is safe, but it needs subcutaneous injection. The results of four studies showed that after 6 months of treatment (1.6mg twice a week), HBeAg and HBV DNA turned negative and ALT decreased to normal in 36% of the 183 patients. In contrast, only 19% of the 111 untreated control patients were effective.

Carefully seek medical advice and choose drugs

At present, in terms of drug selection for hepatitis treatment at home and abroad, the encyclopedia includes three aspects: (1) antiviral drugs; (2) immunomodulators: (3) drugs that promote the repair and regeneration of liver cells.

There are many kinds of drugs used to treat viral hepatitis. It is estimated that there are more than 7 kinds of drugs used to treat hepatitis (including hepatoprotective drugs, antiviral drugs and drugs for regulating immune function) in China. In the treatment of protecting liver function and preventing further necrosis of liver cells, the progress is still remarkable. For example, the mortality rate of severe hepatitis was as high as 8% in the 196s and 197s, but it has dropped to about 4% in the 198s and 199s, which shows that the measures to prevent hepatocyte necrosis and promote hepatocyte regeneration have taken a great step forward, but so far there is no specific drug that can radically cure viral hepatitis. However, various media's propaganda on hepatitis treatment is exaggerated, saying that "hepatitis can be cured radically" and "* * drugs have the best curative effect on hepatitis" violate scientific laws, and absurd and bizarre advertisements are common, such as claiming to be "the king of changing yin", "the nemesis of hepatitis", "the difficulty of hepatitis B has been broken" and "all the three positive diseases have turned negative", "solving the urgent needs of hundreds of millions of hepatitis patients in China"

Recently, many hepatitis experts have called for correct media publicity and don't mislead patients into being deceived. It is pointed out that the therapeutic purpose of hepatitis B is not to turn negative all kinds of virus markers, but to prevent hepatitis from developing into chronic and fibrosis. At present, there is no "magic medicine" to eliminate the spread of hepatitis B virus, and there is no provision to take the negative mark of hepatitis B virus as the therapeutic standard. As mentioned above, although there are many drugs for the treatment of viral hepatitis, especially chronic hepatitis, so far there is no drug that can radically cure hepatitis B virus. Based on this reason, the author thinks that people with hepatitis B "big three yang", "small three yang" and "1.5 yang" or patients with mild transaminase elevation and hepatitis C transaminase elevation should not ask for people like "turning to yin" everywhere. Our countermeasures are: we should focus on basic treatment, that is, proper rest, maintaining optimistic mood, reasonable diet, supplementing enough nutrition and choosing appropriate health food, which have a very good effect on protecting liver function and preventing chronic hepatitis and fibrosis. For those patients with severe hepatitis, it is best to be hospitalized for systematic treatment.