Are people who carry the BRCA gene more likely to develop cancer?

Predisposition to breast and breast cancers, especially those with BRCA mutations and familial multiple colon polyps, increases the risk. It is recommended that you usually strengthen your resistance and go to the hospital for regular check-ups. In China, preventive mastectomies are not recommended, which allow for shorter check-up intervals and prompt surgical treatment when signs of cancer appear. Breast color Doppler ultrasound and mammography are effective methods for detecting early breast cancer.

Women aged 40-50 should go to a professional medical institution for a professional standard breast examination and B-ultrasound examination every one to one and a half years. The frequency of mammography should follow the recommendations of professional doctors; it is recommended that elderly people over 50 years old should check B-ultrasound and mammography once a year; as age increases, such as over 70 years old, the frequency of examinations will decrease; women aged 20-40 should also Check every 2-3 years.

The human BRCA1 and BRCA2 genes are important genes on human chromosomes 17 and 13 respectively. The proteins it expresses play an important role in maintaining the stability of the human genome. Mutations in BRCA1 and BRCA2 are highly associated with familial breast cancer. By detecting BRCA1/2 gene mutations, we can screen out high-risk groups for breast cancer, identify mutations in related genes in families, and assess the risk of breast cancer in susceptible groups. Genetic variants not only cause premature menopause but also increase the risk of infertility.

The American Institute for Cancer Research states that mutations in BRCA1 or BRCA2 are the main causes of breast cancer. Women who carry these mutations are five times more likely to develop breast cancer. BRCA-2 and BRCA1 mutations are autosomal dominant, but this does not mean that all mutation carriers will develop cancer. However, people with BRCA-2 gene mutations have a greatly increased risk of developing cancer. The detection of this gene mutation also requires alerting to the possibility of ovarian cancer in addition to breast cancer, so these two related diseases are called hereditary ovarian cancer-breast cancer syndrome.