If you travel by yourself, what is the most suitable route from Hefei to Nanjing, Huangshan, Suzhou, Hangzhou and Shanghai?

Almost enough. Go to Huangshan first or finally, and visit other cities from south to north or vice versa. After all, there are many convenient buses from Huangshan to Hefei, and then from Huangshan to Hangzhou, or first visit the cities in East China and finally visit Hangzhou. Take a bus from Hangzhou to Huangshan, swim in Huangshan and then take a bus back to Hefei.