Will it be okay for the dog to stay at home alone when the whole family goes out for four days and three nights?

My friends and I both have dogs and are familiar with each other's dogs. Friends usually go out for two or three days. We go to her house twice a day to help walk the dog and add water and food. It's normal to urinate, but we eat and drink very little because of sadness. My dog is sensitive, so he will be scared at home and have a bad temper. Once I went out to play with my partner for a few days. Although my friend came to walk the dog every day to replenish water and food, I was afraid and angry at home and once peed directly on the sofa. But my friends and I never dare to put the dog in each other's house when we go out ... The familiar place is that it gets an acre of land. In addition, be sure to close the doors and windows. There are no other big problems.