When liver cancer occurs, what are the abnormal changes in the skin?

Below, Dr. Long will analyze and summarize several skin manifestations related to liver cancer:

1. pityriasis cutis

The main manifestations are multiple round or oval pityriasis with clear boundaries, patchy lesions and scales. Pityriasis cutis suggests that there may be liver cancer, which is a useful diagnostic sign, especially for some chronic hepatitis B virus infected people, the skin is dark.

2. Delayed cutaneous porphyria

Delayed dermatophytosis is a relatively rare skin disease, mainly manifested as erythema, blisters and bullae after sun exposure or minor skin trauma. These blisters may bleed, so patients with chronic hepatitis C should pay attention.

3. Multiple seborrheic keratosis

Also known as Lesar-Trelat sign, patients' skin lesions mainly show eczema-like basal inflammatory reaction, which may be accompanied by vegetation and acanthosis nigricans.

4. Pemphigus

Deciduous pemphigus is an epidermal vesicular skin disease similar to pemphigus vulgaris. This skin disease rarely involves mucous membrane, and its blisters often show superficial erosion, accompanied by erythema, scales and scab formation, similar to severe seborrheic dermatitis.

5. Dermatomyositis

Dermatomyositis is a disease with various manifestations. Dermatomyositis associated with liver cancer is characterized by scaly purple papules on the extension side of the hand, purple patches on the skin around the eyes, heterogeneous patches on the skin in the light area, patches and scaly patches on the scalp and inner thighs, or periungual telangiectasia and rough skin.

Questions and answers are the most attentive, Dr. Juan Carlos valerondo!

Lifestyle public health believes that the recognized changes of skin are liver palm, spider nevus, abdominal vein exposure, and some will have skin jaundice. Liver cancer is the "king of cancer", and the three basic metabolites of sugar, protein and fat are all completed in the liver. It is also a detoxification organ, and the metabolism of vitamins and hormones is also carried out in the liver, so liver cancer is too dangerous. You can't just look at the abnormal changes of the skin, because the liver is undergoing the above-mentioned important biochemical reactions, and it was discovered in the late stage, so it is better to pay attention to all aspects of observation.

Traditional Chinese medicine believes that the liver governs the discharge, and if you feel irritable, your chest, abdomen and ribs are uncomfortable, it may be related to the change of liver function. The main muscle of the liver, if you feel that the tendons are inflexible, stretched and muscles sometimes tremble, it has something to do with the liver. In other words, we should pay attention to it at ordinary times, and don't wait until the liver is too tired or has liver function problems to avoid liver damage. In other words, the occurrence of cancer is generally a lump formed by long-term accumulation for many years. Usually pay attention to avoid the occurrence of major diseases.

Life-oriented public health advice, usually pay attention to drink less or not, live regularly every day, get enough sleep and exercise moderately. Keep a good mood and don't eat too fat, too sweet or too greasy food in your diet. In short, we should pay attention to maintaining ourselves.

Possible skin abnormalities of liver cancer include:

The most typical ones are liver palm and spider nevus. The liver palm is characterized by patchy congestion at the thenar of the thumb and little finger of the palm, or red spots and plaques, which become pale after compression. Spider nevus is a nevus body formed by the expansion of the terminal branches of cutaneous arterioles, which is centered on a central point and surrounded by radial branches of small blood vessels. Because it looks like a spider, it is called spider nevus, which usually occurs in the area where the superior vena cava is distributed (face and neck, upper chest and shoulders, etc.). ). In fact, they are all manifestations after hepatitis and cirrhosis, and they are not unique manifestations of liver cancer. Therefore, this lesion can only be said to be liver abnormality and cirrhosis, but not liver cancer. This needs further examination. Many liver cancers do have hepatitis cirrhosis, but not necessarily, so there are not necessarily signs of liver palm and spider nevus.

Liver cancer may also have itching, which is skin itching caused by cholestasis caused by liver cancer. But also because of cholestasis, bilirubin increases, jaundice will occur, that is, yellow staining of skin or mucosa.

When liver diseases, including liver cancer, develop to a certain extent, there will be a so-called liver disease face, which can also be regarded as a skin manifestation, showing that the patient's skin is pigmented, dull, gray or even gray-black.

Speaking of liver cancer, this kind of cancer is actually terrible. There is almost no cure except liver transplantation. Liver cancer is mainly a malignant tumor that occurs in hepatocytes and intrahepatic bile duct cells for various reasons. Up to now, the pathogenesis of liver cancer is still unclear, but there are many inducing factors.

The most common inducing factor of liver cancer is hepatitis B virus, mainly the abnormal gene expression caused by hepatocyte DNA. There is also cirrhosis, which is mainly caused by atypical hyperplasia in the liver after hepatocyte injury. In addition, there are cholestasis, excessive alcohol, liver congestion, Aspergillus flavus infection, chemical poisoning and other factors.

However, the incidence of liver cancer is hidden, and the early symptoms are not obvious, but in the middle and late stage, there will be pain in the right upper abdomen (liver area), abdominal distension and pain in the right shoulder and back, and the rupture of liver cancer nodules will lead to severe and persistent abdominal pain. Some painkillers have no effect, which can also lead to symptoms such as decreased food intake, nausea and vomiting, malnutrition, emaciation, loss of appetite, systemic infection, etc. At night, after cancer cells metastasize, there will be symptoms of various tissues and organs.

However, after the appearance of liver cancer, the skin will also have symptoms, mainly the following!

1, skin itching, because liver cancer leads to abnormal operation of liver bile, but skin itching is not necessarily liver cancer, but if people such as hepatitis have unexplained skin itching and the use of antipruritic drugs has no effect, we should be wary of liver cancer. Many cancers with high malignancy can lead to skin rashes and erythema on the surface of the body.

2. Spider nevus and spider nevus appear in the palm. The causes of liver palmar nevus and spider nevus in patients with liver disease are basically the same. Because of abnormal liver function, estrogen can't be treated, which leads to too much estrogen acting on arterioles and dilating them. In addition, because some vasodilators remain in the blood, the contractile function of sphincter cells is reduced, and more blood passes through arterioles, which increases the pressure on the blood vessel wall, makes the blood vessel bend and spiral, extends to the area with the lowest skin tension, and finally forms spider nevus.

3. Yellowing of the skin, mainly manifested in the face and iris, is mainly due to abnormal liver function caused by liver cancer, which increases serum bilirubin in blood vessels, leading to yellowing of the skin and iris, while abnormal hormones lead to gloomy face.

Liver cancer is one of the common malignant tumors in China, with high malignancy, rapid progress and great harm. Patients with liver cancer will also have abnormal changes in their skin.

Causes of liver cancer Most liver cancers are transformed from chronic liver diseases. There are many causes of liver cancer, and the most common cause in China is hepatitis B virus infection. In addition, hepatitis C virus infection, alcoholism, fatty liver, eating moldy food, chemicals and hereditary metabolic liver disease may all lead to liver cancer.

The "specific function" of liver cancer cells The cancer cells of liver cancer have many functions, but these normal liver cells do not.

1. Infinite growth and division: Cancer cells are different from normal human cells in that their growth is unrestricted. As long as human life exists, the growth of cancer cells will not stop.

2. Predator of human nutrition: This is another important feature of cancer cells. It can establish its own arterial blood vessels and use them as its own nutritional channels. In order to meet the needs of their crazy growth, they absorb nutrition, while other tissues and organs of the human body are undernourished.

3. Savage invaders: This is another important feature of cancer cells. It not only grows by itself, but also invades other tissues and organs. If it directly penetrates into adjacent tissues and organs, it can also invade away from its own tissues and organs through lymph and blood.

Skin manifestations of patients with liver cancer As the saying goes, geese fly and sound, and the wind flies away. Everything has clues, internal and external laws, and diseases are no exception.

The liver is the largest gland of human beings, which has many functions such as synthesis, metabolism, secretion, regulation and transportation. Also known as the "chemical plant" of the human body.

When liver cancer appears in human body, it may not be obvious now because the early liver cancer has little influence on human body. However, with the development of liver cancer, liver damage is aggravated, which leads to abnormal changes in liver function and changes in human appearance.

1. Facial skin becomes dull: due to the decline of liver function, the explanatory function of the liver decreases, and endotoxin in the human body increases, showing dullness on the face, which is called chronic liver disease.

2. Formation of liver palmar nevus and spider nevus: In the terminal stage of liver cancer, liver cancer cells account for half of the country, even more, normal liver tissue is few, liver inactivation ability decreases, and estrogen in human body increases, which is manifested as spider nevus and liver palmar nevus on human skin.

3. The "blue veins" of the abdominal wall are exposed: Liver cancer can cause abnormal changes in the structure of the liver, and the blood flowing through the liver is blocked, leading to portal hypertension. Because of portal hypertension, blood initially shunts through the liver, and abdominal vein is one of them. Due to the increase of blood, the abdominal vein is exposed, commonly known as "blue veins", which is actually varicose veins.

4. Yellow skin and sclera: As we all know, the liver is an important organ for bilirubin anabolism. When liver cancer occurs, bilirubin synthesis and metabolism are impaired, and bilirubin in the body increases, leading to yellow staining of skin and sclera. For example, the tumor of liver cancer compresses the bile duct, and bilirubin increases more obviously, which is called severe yellow staining of skin and sclera.

5. Edema and depression of lower limbs: The liver has many functions, one of which is synthetic albumin. When albumin in the human body drops, it often indicates that the liver is seriously damaged. This phenomenon often occurs in the late stage of liver cancer. Due to hypoalbuminemia, the osmotic pressure of blood decreases, and the water in blood seeps out of the surrounding tissues. When water flows downwards, it first manifests as edema of lower limbs.

Although the above skin manifestations are not unique to patients with liver cancer, if they appear in patients with liver cancer, they often indicate that they have reached the advanced stage of liver cancer and their condition is very serious. Of course, in addition to skin manifestations, there are pain and emaciation in the liver area.

How to prevent the occurrence of liver cancer, early detection of liver cancer Once patients with liver cancer have abnormal emotions, they often reach the late stage of the disease and miss the best treatment opportunity. Therefore, the prevention and treatment of liver cancer is of great significance. Early detection, early diagnosis and early treatment can achieve the best results, and even achieve the purpose of rehabilitation.

1. For the high-risk population of liver cancer, that is, the population prone to liver cancer, we should actively treat the primary disease. For example, patients with hepatitis B and hepatitis C should be treated with anti-virus and liver protection to reduce the possibility of cancer of liver cells.

2. Change the bad behavior of injury. Eat more fresh fruits and vegetables, not greasy, pickled, fried and moldy food; Develop a good schedule and don't stay up late; Quit smoking and drinking; Peace of mind; Proper aerobic exercise to lose weight.

3. Go to the hospital for screening regularly. High-risk patients with liver cancer went to the hospital for liver function, alpha-fetoprotein, B-ultrasound and CT examination from March to June. Small liver cancer can be found.

In the decompensated stage of liver cirrhosis or the stage of liver cancer, due to the decline of liver function and endocrine disorder, there will be many systemic symptoms, among which abnormal skin changes are typical. Let me study with you.

When liver cancer occurs, what are the abnormal changes in the skin? 1. Dark complexion: For patients with liver disease, when the liver function drops obviously, liver disease will appear, which is characterized by dark complexion, dull complexion and rough and dull skin. Especially around the eyes, it is more obvious, a bit like dark circles.

2. Yellowing of skin and sclera: Yellowing of skin and sclera is due to the decrease of liver's ability to metabolize bilirubin and the increase of indirect bilirubin level in blood, which causes jaundice. Because bile salts are deposited on the skin, it will cause itching of the skin.

3. Spider nevus of the liver palm: The liver palm is characterized by redness at the thenar and spider-like spider nevus, which are all caused by abnormal metabolism of estrogen by the liver. It is a typical manifestation of decreased liver function.

Liver cancer is difficult to find in the early stage, because it has no pain nerve, so it is called "silent cancer king". In fact, when liver cancer is about to happen, there will be abnormalities in the body and great changes in the skin:

Long-term severe insomnia. If a person can't sleep normally from 1 to 3 pm, we must pay enough attention to it. Because 65438+ 0: 00 to 3: 00 p.m. is the most vigorous time for the liver meridian to run qi and blood, and it is also the busiest time for the liver. A lot of blood in the body will flow into the liver, and the liver will detoxify. If you can't sleep at this time, it will definitely affect the detoxification function of the liver, make toxins stay in the liver, and plant seeds for the formation of liver cancer.

Emotional disorder. Under normal circumstances, because the liver has the function of regulating the whole body qi, when the mood is normal and the mood is comfortable, the qi and blood of the human body will proceed peacefully and orderly and will not get sick. If a person is angry, unhappy, sentimental, sad and crying for a long time. It is easy for liver qi to stagnate, leading to liver blood stagnation, which will induce liver cancer over time.

Unexplained red spots appear on the skin of the body. The red spots are divergent bloodshot, which may be "spider nevus". Related to liver cirrhosis and liver cancer.

Dark red changes appear on the palm skin. Under normal circumstances, the blood in the human body will flow into the liver from/kloc-0 to 3 am, and the blood quality is good without any problems. During this period, the liver will smoothly detoxify and let the blood flow into the heart. In this case, our palms are pink. If the liver has a tumor or cirrhosis, people will suddenly wake up at 1 and can't sleep anymore. During this period, a large amount of blood in the body will become smaller because of tumors or cirrhosis in the liver, and it is too late to detoxify the blood. Toxins will flow into the heart with the blood, which will lead to the deepening of the blood and accumulate in the palm for a long time, which will turn dark red.

The edema and ascites of liver cancer appear in people's lower limbs, which aggravates the pain of patients and can be life-threatening in severe cases.

In the late stage of liver cancer, there will be bleeding tendency and ecchymosis on the skin.

To sum up, when liver cancer is about to happen, the body will send us a distress signal. Therefore, once the body is abnormal, it is necessary to adjust it in time to prevent the disease from developing. Keep a happy mood, smile and eat a healthy and reasonable diet in daily life. Never eat moldy things, such as melon seeds, peanuts and grain, because these things contain aflatoxin, which is a carcinogen. Ensure adequate sleep time, exercise properly and live a healthy life!

Hello! I'm Dr. Xiangzi @ Forest, and I'll answer the question: What are the abnormal changes in the skin when liver cancer occurs? This question. Modern medical diagnosis includes sight, touch, knock and hearing; The diagnosis of traditional medicine is observation, hearing, questioning and diagnosis. Both Chinese and western medicine focus on examination or wait-and-see, that is, observing and analyzing the condition through the external manifestations of patients.

Huangdi Neijing says that "there must be external causes for internal causes", which means that diseases inside the human body must have external changes.

@ Doctor @ Forest Xiangzi

For example, if you see a patient with deficiency of both qi and blood, you can judge that this person has deficiency of both qi and blood just by "observing words and feelings", such as pale face, pale lips and nail bed, lazy speech, listlessness, indifferent expression and low voice.

Engaged in internal medicine for decades, I have seen many abnormal skin changes in patients with liver disease, especially in patients with liver cancer, which is more common. Now I will introduce them one by one as follows.

1. Jaundice Jaundice generally occurs in the late stage of liver cancer, which can be caused by liver cell injury, bile duct obstruction caused by cancer block pressing or invading bile duct near hepatic portal, or by cancer tissue and blood clot falling off.

Second, patients with pigmented liver disease have metabolic disorders, endocrine disorders, and increased melanin in the basal layer of epidermis, which leads to deepening skin color. The exposed parts of the body and the pigmentation around nipples, armpits, reproductive organs, joints and anus are dark.

Pigmentation appears on the cheeks of patients with liver disease, which is also called "liver spot" clinically.

Third, spider nevus, liver palm spider nevus is a vascular nevus formed by the expansion of the terminal branches of cutaneous arterioles, which looks like a spider, so it is called spider nevus.

Spider nevus mostly occurs in the distribution area of superior vena cava, such as face, neck, back of hand, upper arm, chest and shoulders.

Spider nevus vary in size, ranging in diameter from hat needles to several centimeters or more. During the examination, press the center of spider nevus with fingertips or matchsticks. When pressing, the radial vascular network disappears and reappears after the pressure is released.

But some people have one, two or several spider moles, and they don't necessarily have liver disease. Healthy women can also appear during pregnancy.

Clinically, it is found that the palm and thenar of many patients with liver disease often turn red, and then turn pale after being pressed, which is called liver palm. The pathogenesis of liver palm is the same as that of spider nevus.

4. Warts and warts are caused by human papillomavirus (HPV) infection, which can cause malignant transformation. Common warts include common warts, plantar warts, flat warts and condyloma acuminatum. Different clinical types are caused by different types of human papillomavirus, and people are the only host of this virus.

The wart virus is transmitted through direct contact and occasionally indirectly through pollutants. Skin trauma is an important factor of viral infection.

The occurrence and regression of warts have a certain relationship with human immune function, and cellular immunity plays a major role in the defense mechanism of warts. The incidence of warts in immunocompromised people is higher than that in normal people.

Patients with liver cancer have warts on their skin, which are mostly caused by viral infection caused by decreased immunity.

Warts can appear around the neck, back, upper and lower limbs, genitals or anus.

The above is Dr. @ Forest Xiangzi's answer to your question. I hope it helps you.

Tip: The picture comes from the Internet.

1, itchy skin

Of course, it is also ruled out that it is caused by some factors such as dry weather and allergies. If it is persistent itching and the medication has not improved, it will attract attention.

2, the skin is black

Such as the skin on the face, forehead, etc. It is dark, which often indicates that there is something wrong with the organs, possibly the kidneys and liver, so it is necessary to do relevant examinations in time.

3, long skin mole

Spider-shaped red nevus is generally distributed around the abdomen or navel, and its surface looks like a spider, so it is named spider nevus.

4. Yellow skin

It is generally believed to be related to liver metabolism, because the liver secretes bile. If the secretion is abnormal, the bile duct will secrete to the whole body, making the skin yellow, so it looks like yellow skin, which is generally called "jaundice" in medicine.

How to prevent liver cancer?

Prevent hepatitis B.

Injection of hepatitis B vaccine, if infected with hepatitis B should be treated as soon as possible;

Don't eat bad food.

Take care of the food at home. Don't eat it if it is found to be spoiled or moldy.

Appropriate selenium supplementation

You can eat some selenium polysaccharide, selenium-enriched yeast and so on. Eat some fresh vegetables and fruits;

a regular health checkup

Regular physical examination can keep abreast of your health status.

The human body is a whole and the skin is closely related to the whole body. Many systemic diseases can be reflected on the skin. When the liver is diseased, it can affect the combination or regulation mechanism of synthesis and excretion, thus causing changes in skin structure and function. Liver cancer can also cause skin changes. Before answering the question, I would like to remind you that the following symptoms can't diagnose liver cancer, they are just clues to liver cancer, so don't sit in the right place easily! The real diagnosis of liver cancer needs the help of ultrasound, CT, histopathology and other auxiliary examination methods, and the diagnosis is made by a specialist.

When the following five skin abnormalities occur, it may be that cancer cells have taken root and sprouted in the liver:

1. Itchy all over.

When cancer cells grow wildly and block the bile duct in the liver, resulting in cholestasis, patients may have itchy skin. This is due to cholestasis, bile salts in bile combine with bilirubin and return to the blood, which flows to the whole body with blood circulation. However, bile salts are deposited on the skin, which stimulates the sensory nerve endings in the skin and makes the patient itch all over.

Step 2 face liver disease

Many liver diseases will show signs of liver disease, including liver cancer. The main manifestations are pigmentation of the patient's facial skin, especially the skin around the orbit, and the skin loses its luster, making the whole facial skin appear gray or even gray-black.

3. Yellow skin staining

Yellow skin dyeing is called jaundice in medicine, which is mainly manifested as yellowing of skin mucosa. The initial feature is that the whites of the eyes are yellow, and with the development of the disease, the whole body skin will turn dark yellow or yellowish brown. Its pathogenesis is the same as skin itching, and it is also caused by the increase of bilirubin in blood.

4. Spider nevus

It is a small intertwined blood vessel, emanating from a red dot. There is a central artery in the middle of the red dot, and there is a faint circle around it, which is as big as 50px from the needle. The whole mole looks like a spider, hence its name. The giant spider nevus can see or feel the pulsation, especially when pressed with a glass slide. Spider nevus is mainly distributed in the upper chest, forearm, hand and face.

5. liver palm

When liver cancer leads to liver function damage, liver palm will appear. Mainly manifested as pink spots or patches on the palmar surface and fingertips of thenar and thenar muscles on both sides of the palms of both hands. The color is cinnabar, which can turn white immediately after pressing, and turn red soon after not pressing, while the palm color is normal. The whole palm looks red outside and white.

In addition to liver cancer, these lesions will have the same or similar manifestations in chronic viral hepatitis, cirrhosis and liver failure. Therefore, when one of the above skin changes occurs, the liver may have problems. Please go to the hospital in time for early detection and treatment.