The lady eats a catty of litchi, which leads to diabetic ketosis. Can it also lead to liver damage?

The weather began to get hot in June, and the fruits of the season were slowly freshly baked. Litchi is one of them. Peeling off the shell and taking a bite contains sweetness and love for this summer. It's delicious!

But if you love litchi, you must know how to control it, or you will get litchi disease!

Recently, there was such a news that a woman in Huizhou bought a catty of lychee because she loved it, ate it all at once, and then had symptoms such as dizziness, fatigue and nausea, and immediately went to the hospital for emergency treatment;

It turned out that she ate too much litchi at one time, and as a result, her-hydroxybutyric acid was as high as 2000 umol/L, while that of normal people was between 20 and 200 umol/L. When the-hydroxybutyric acid was higher than 600umol/L, it was severe diabetic ketosis.

After examination, the lady was diagnosed with diabetic ketosis, and the culprit was that catty of litchi!

The main manifestations of diabetic ketosis are obvious increase of blood sugar, generally 16.7 ~ 33.3 mmol/L, sometimes more than 55mol, increased blood and urine ketone bodies, dehydration, electrolyte disorder, metabolic acidosis, etc. And the aggravation of diabetes symptoms, such as excessive drinking, excessive urine, thirst, limb weakness, weight loss and so on.

With the progress of the disease, most patients have anorexia, dizziness, headache, nausea and vomiting, listlessness, and a few patients may have abdominal pain, similar to acute abdomen, which is easy to be misdiagnosed.

Then drowsiness, deep and rapid breathing, rotten apples in the breath, slow and serious water loss, decreased urine output, sunken eye sockets, and decreased blood pressure. If it develops further, it will be unresponsive, sleepy and unconscious.

If diabetic ketosis is not well controlled, it may also cause liver damage!

The liver is the largest digestive gland in the body, which participates in carbohydrate and lipid metabolism, but persistent hyperglycemia may affect the normal metabolism of the liver, and improper use of hypoglycemic drugs will inevitably damage the liver function.

In addition, abnormal liver function will aggravate insulin resistance and glucose metabolism disorder, so liver disease and diabetes are interacting and influencing each other.

Diabetic ketoacidosis (DKA) is also closely related to liver injury. The results showed that serum total bilirubin concentration and alanine aminotransferase activity were positively correlated with urine acetone concentration.

When studying the pathology of bovine liver with severe ketosis, scientists found that the hepatic sinuses were reduced, the hepatocytes were enlarged, the fatty components in the liver were increased, the glycogen and Golgi apparatus in the liver parenchyma were reduced, and the smooth endoplasmic reticulum in the hepatocytes was increased.

The mechanism may be that diabetic patients often have microcirculation disturbance, vascular permeability changes and oxygen diffusion function decreases, while ketoacidosis aggravates organ hypoxia and leads to organ damage.

The research results of domestic scholars on DKA patients with liver injury show that acidosis and dehydration are closely related to liver injury, which may participate in the pathological changes of liver cell injury, affect liver microcirculation and cause liver ischemia and hypoxia changes.

It leads to the decrease of liver energy supply, the impairment of liver mitochondrial function, the disorder of cell oxidation process, and finally the degeneration and necrosis of liver cells. With the aggravation of liver function damage, acidosis and dehydration are also aggravated.

In acidosis, the pH value of blood decreases, which reduces the permeability of cell membrane and makes the enzyme easy to release.

At the same time, ischemia can cause decreased oxygen supply, increased oxygen consumption, carbon dioxide accumulation, acidosis, decreased phosphorylation ability of hepatocytes, disordered bilirubin metabolism, increased ALTAST activity and even hepatocyte necrosis.

In addition, the incidence of liver damage in patients with 1 diabetes is significantly higher than that in patients with type 2 diabetes, which may be related to poor blood sugar control and frequent ketosis in patients with 1 diabetes.

Poor blood sugar control will lead to the increase of glycoprotein content, the thickening of capillary basement membrane and the deformation and destruction of red blood cells, thus reducing the energy supply of the liver and leading to liver function damage. DKA disease on this basis will lead to more serious liver damage.

The liver is the great supervisor. As long as he is in good health, everything in your body is fine, but if the liver is not good, various diseases will follow and it is difficult to treat. Therefore, we should take good care of the liver and keep the disease away from us.

# Liver injury # # Diabetic ketosis # # Liver injury #