I drank alcohol last night and took cephalosporin this morning. Will anything happen?

Disulfiram-like reaction, also known as disulfiram-like reaction, is a poisoning caused by "acetaldehyde accumulation" in the body after taking drugs (cephalosporins) and drinking alcoholic beverages (or coming into contact with alcohol). reaction. After alcohol enters the body, it is first oxidized into "acetaldehyde" through the action of "alcohol dehydrogenase" in the liver cells. Acetaldehyde is oxidized into "acetic acid and acetaldehyde" through the action of "acetaldehyde dehydrogenase" in the mitochondria of the liver cells. Enzyme A", acetic acid is further metabolized into carbon dioxide and water and excreted from the body. Because some chemical structures contain "methylthiotetrazole side chains", the activity of acetaldehyde dehydrogenase in the mitochondria of liver cells is inhibited, so that acetaldehyde cannot be further oxidized and metabolized after it is produced, resulting in the accumulation of acetaldehyde in the body and the occurrence of double Thiran-like reaction.

Disulfiram is an alcohol withdrawal drug. After taking this drug, even a small amount of alcohol will cause severe discomfort to the body, thus achieving the purpose of alcohol withdrawal.

Drinking alcohol (or coming into contact with alcohol) while taking the medicine is characterized by chest tightness, shortness of breath, laryngeal edema, cyanosis of the lips, difficulty breathing, increased heart rate, decreased blood pressure, weakness in the limbs, facial flushing, sweating, insomnia, and headache. , nausea, vomiting, dizziness, drowsiness, hallucinations, trance, and even anaphylactic shock, with blood pressure dropping to 60~70/30~40mmHg, accompanied by loss of consciousness. It is easy to be misdiagnosed as acute coronary syndrome, heart failure, etc. In addition, the severity of disulfiram-like reactions is directly proportional to the dose of the drug and the amount of alcohol consumed. The reaction of drinking liquor is more severe than that of beer and alcoholic beverages, and the reaction of drinking alcohol during medication is more severe than that of drinking after stopping medication.

Drugs that cause disulfiram-like reactions include cephalosporins and imidazole derivatives. Among the cephalosporin drugs, cefoperazone, cefoperazone-sulbactam, ceftriaxone, cefazolin (Pioneer V), cefradine (Pioneer VI), cefmetazole, cefminox, and laxazone Cephalosporins, cefmenoxime, cefamandole, cephalexin (Pioneer IV), cefaclor, etc. Among them, cefoperazone has the most reports of disulfiram-like reactions and is the most sensitive. If a patient eats alcohol after using it, Chocolate, taking Huoxiang Zhengqi water, or even just treating the skin with alcohol can also cause a disulfiram-like reaction. Cefotaxime, ceftazidime, cefsulodin, ceftizoxime, and cefixime do not contain methylthiotetrazole groups, so drinking alcohol during use will not cause disulfiram-like reactions.

In addition, metronidazole (Metronidazole can inhibit the metabolism of alcohol, and drinking alcohol after taking the drug may cause abdominal pain, vomiting, headache and other symptoms), tinidazole, ketoconazole, furazolidone, chloramphenicol, toluene Sulfbutamide, glibenclamide, phenformin, etc. can all cause disulfiram-like reactions.

The following nursing measures should be taken for patients with disulfiram-like reactions and anaphylactic shock:

(1) Bed rest, and patients with shock should adopt a "V" shape position.

(2) Keep the respiratory tract open and provide oxygen inhalation of 4-6L/min to improve tissue hypoxia.

(3) Establish an intravenous channel, follow the doctor's instructions and give 5 to 10 mg of dexamethasone added to glucose solution for intravenous infusion or intravenous push, rehydration and diuresis, and give vasoactive drug treatment according to the condition.

(4) Symptomatic treatment. If you have nausea and vomiting, you can give metoclopramide 10 mg intramuscularly; if you are drowsy and unconscious, you can give naloxone as countermeasures.

(5) Prepare emergency equipment and medicines at the bedside, such as defibrillators, sputum suction devices, tracheotomy and venous incision kits, respiratory stimulants, diuretics and other rescue medicines.

(6) Closely observe the patient’s consciousness, body temperature, pulse, respiration, heart rate, heart rhythm, blood pressure, urine output and other clinical changes, and keep a nursing record of the patient’s condition.

Remember the last time you were drunk

As the name suggests, we mean "drunk" rather than "drunk".

For most people, "drinking a glass of wine" has long meant a happy time with friends talking and laughing. Depending on our age, and on the circumstances which surrounded our first experiences with alcohol, we all have various memories and hopes (sometimes, anxieties) aroused by the thought of a cool beer, a martini, a gin and Quartz. Ninja water, whiskey and beer, a sip of wine or something like that and so on.

Time and again, in the early stages of most people’s drinking experience, their expectations for alcohol always meet the actual amount of alcohol they need to drink.

If it happens to be just right every time, we naturally think of "having a glass of wine" as a pleasant experience that not only meets our own needs, but also does not go beyond the norms of religious customs. At the same time, it satisfies desires, caters to the etiquette of social occasions, and helps us relax, cheer up, and achieve our various pursuits. For example, it is a 55-year-old Finn, when someone offers him a drink, it will immediately remind him of the negative emotions that experienced when he drank a glass or two of brandy or vodka on a cold day in his youth. Waves of warmth.

If she is a young woman, she may immediately think of a gorgeous crystal glass filled with champagne, fragrant clothes, a romantic atmosphere of rubbing ears and temples together, or a beard and long hair in a rock concert. A young man wearing a denim suit took out a bottle of booze from a bag full of bottles. Flashing lights kept flashing, smoke was everywhere, and everyone screamed. It was an exciting scene. One AA member said: "Have a drink" is almost synonymous with eating pizza and drinking beer.

There is also a 78-year-old widow who said that she often couldn't help but think of her habit of having a glass of sherry at bedtime when she was in a nursing home. Although this image of drinking in our minds is extremely natural, in our current situation, it is misleading, and it is how some of us start drinking.

If this is all we do with drinking, we are less likely to develop an alcohol problem later on. Yet a fearless look at our complete drinking record, however, shows that in the last years and months our drinking never created those perfect, magic moments again, no matter how hard we tried.

Instead, over and over, we wound up drinking far more than that, eventually landing in some kind of trouble as a result. Maybe we're simply guilty, secretly, of drinking too much.

But sometimes it can turn into violent quarrels, affecting one's own work, or even leading to serious illness, accidents, or legal and financial problems. So when the suggestion of "a drink" comes to us, we now try to remember the whole train of consequences of starting with just "a drink" and ending with our last miserable drunk and hangover.

Generally speaking, when a friend invites us to drink a glass of wine, it simply refers to a way of socializing and just tasting one or two glasses.

But if we are careful to recall the full suffering of our last drinking episode, we will be free from our long- ago notion of "a drink." deceived.

Now we can honestly admit that, in terms of our physiological reality, we are pretty sure that drinking a glass of soup means that sooner or later we will be drunk again, which will bring a series of troubles.

Drinking no longer means music and joy to us, but the memory of illness and regret. An AA member once said: "I know that if I go to a bar to drink a glass of wine now, it will never be the same as before. It just takes a little time and spends some money.

This glass of wine will It was too costly and too high a risk to drain my bank account, my family, my house, my car, my job, my sanity, and my life.”

He. Remembering the last time he got drunk, not the first experience.