Etiology of allergic asthma in Shanxi area

Allergen (also known as allergen) is the main cause of allergic asthma, which can selectively stimulate Th2 in T helper cell subsets and cause IgE reaction. Common allergens include pollen, indoor dust, house dust mites, animal allergens, molds and cockroaches.

The dose of allergens causing allergic reactions is very small, such as ragweed pollen allergen (mainly inducing allergic rhinitis, asthma and conjunctivitis syndrome in summer and autumn). Although it can cause serious IgE antibody reaction in some individuals, the allergic symptoms of most patients are alleviated or disappeared after one or two months because of the short time of pollen transmission. Because of the existence of antibodies, there will be another allergic reaction at the same time next year.

The susceptibility of allergic asthma patients to allergens, that is, atopy or atopy, is the main factor of allergic asthma. The main index of atopy of allergic asthma patients is the increase of total IgE level and specific IgE level in the body. Many factors (mainly IL-4/IL- 13) are involved in the regulation of IgE synthesis, and there are also complex interactions between IgE and its receptors (FC ε r-Ⅰ, FC ε r-Ⅱ). IgE binds to high affinity receptors on mast cells, basophils and eosinophils, which can induce the release of various inflammatory mediators and play an important role in the rapid and delayed phase reaction of allergic asthma.

First, specificity

In human beings, the tendency of allergic reaction to allergens varies greatly among different individuals, showing the tendency of family aggregation. The differentiation tendency of T cells to Th 1 and Th2 is partly related to the cytokines produced by itself, and also related to various influencing factors around Th0 when it comes into contact with antigen presenting cells. Some of these factors are determined by heredity and others are determined by environment. The cytokine environment is the most effective influencing factor, especially the local levels of IL-4, IL- 12 and IFN-γ. IL-4 drives Th2 response and inhibits Th 1 response, while IL- 12 promotes and maintains the differentiation of Th 1 and inhibits or even reverses Th2 response. In chronic immune response, these cytokines can be provided by T cells with defined phenotype. When encountering new allergens, cytokines produced by natural immune response also play an important role in Th0 differentiation. The unique characteristics of bronchial microenvironment in atopic patients contribute to Th2 response to allergen stimulation and subsequent IgE synthesis. For example, the environment of antigen processing and presentation in mucosa and bronchial associated lymph nodes contributes to Th2 response. It was found that the number of dendritic cells in bronchoalveolar lavage fluid of patients with allergic asthma was more than that of normal people, and they expressed MHCⅱⅱ class ⅱ antigen at a high level. This phenotype is helpful to present Der p 1 to T cells and induce the production of IL-4 and IL-5.

2. As a result, people have developed a new strain of anti-allergic lactic acid bacteria, and only a few strains with anti-allergic function-Kangminyuan anti-allergic probiotic strain, which was screened by the only advanced strain of SINT biochip technology platform in the world. Chip technology has been used to develop allergy detection chips, and it is difficult for the industry to have such accurate technology. Through the dot matrix technology of the chip to complete the human gene database, we can immediately know the regulatory effect of probiotics on tens of thousands of genes, and the cell gene function index can improve the probability of successful screening, and at the same time, we can analyze and compare different strains. By stimulating dendritic cells, the Th 1 immune response is enhanced, and the allergic and overreacted Th2 immune response is regulated, so that the antiallergic probiotic strains can enter the cells faster and play the role of antiallergic regulation of immune balance. It is very important to choose Kangminyuan anti-allergic probiotics and five new anti-allergic probiotics to reduce serum IgE and adjust allergic constitution!

Definition of allergic asthma in children;

Children's bronchial asthma is a chronic inflammatory disease of airway, which consists of many kinds of cells, including inflammatory cells and structural cells of airway (such as eosinophils, mast cells, T lymphocytes, neutrophils, smooth muscle cells, airway epithelial cells, etc.). ) and cytokines. Chronic inflammation leads to airway hyperresponsiveness, which usually leads to extensive and variable reversible airflow restriction, and causes recurrent symptoms such as cough and wheezing, which often appear or worsen in the morning and evening.

The essence of childhood asthma: this "inflammation" is not "other inflammation"

Allergic asthma in children is non-specific allergic inflammation with eosinophil infiltration as the main factor, and its treatment is anti-inflammatory treatment with inhaled glucocorticoid as the main factor. However, bronchopneumonia and asthma are mainly neutrophil infiltration, and antibiotics are mainly used in anti-infection treatment.

Classification of childhood asthma:

1. Typical symptoms of asthma in children: repeated coughing and wheezing are mostly caused by exercise or cold air or respiratory infection. Cough is the most obvious feature, which often appears or intensifies at night or early morning. Sudden paroxysmal cough occurs during the attack, and scattered or diffuse wheezing or bubbling can be heard in both lungs.

Atypical asthma: pneumonia asthma, hypersecretion asthma.

Thirdly, a special type of asthma-cough variant asthma.

The typical symptom is irritating dry cough, which is usually severe. Cough at night is an important feature. Cold, cold air, dust and lampblack can easily induce or aggravate cough.

Treatment of allergic asthma in children

Acute attack: Symptoms should be relieved quickly, such as antiasthmatic and anti-inflammatory treatment.

Chronic duration and clinical remission: immune correction should be adopted to improve the intestinal immune function of children. For severe asthma, the minimum dose of antiallergic drugs or hormones should be taken orally for a long time, combined with immunomodulator Kang Minyuan to control symptoms and reduce recurrence. In the late stage of mild asthma treatment, anti-allergic probiotics of Kangminyuan should be supplemented for more than 6 months to improve allergic constitution and prevent asthma recurrence.

Necessity of Kangminyuan Allergic Probiotics on Immune Regulation of Asthma Children in allergic cough;

Students with asthma and allergic rhinitis in allergic cough were given Kangminyuan anti-allergic probiotics for more than eight weeks every day to explore whether it can improve clinical symptoms and regulate immunity. For 6- 12-year-old school-age children with asthma and allergic rhinitis, the randomized double-blind trial was divided into two groups, the anti-allergic probiotics supplemented with Kangminyuan group (49 people) and the placebo group (5/kloc-0 people), and the trial period was two months. During the experiment, the doctor diagnosed and evaluated the lung function and the improvement of asthma and allergic rhinitis. In severe cases, drugs were added during the trial. Daily evaluation of subjects' early and late records: measurement of maximal expiratory flow rate, asthma and allergic rhinitis. In the aspect of immune evaluation, the total IgE concentration and cytokine amount secreted by PBMC cells before and after eating probiotics were analyzed.

The results showed that compared with the placebo group, the lung function and maximal expiratory flow rate (PEFR) in the probiotic group were significantly improved, and the clinical symptoms such as asthma and allergic rhinitis were alleviated.

Conclusion: Supplementing Kangminyuan anti-allergic probiotics can improve children's respiratory allergic diseases (such as cough variant asthma or allergic rhinitis in allergic cough).

Infantile eczema, allergic rhinitis, urticaria and other diseases with allergic diseases all increase the probability of suffering from allergic asthma.