How human thinking is seriously damaged, which will lead to normal and pathological personality. Why is this?

The reasons for the destruction of thinking can be roughly divided into two categories: external causes and internal causes. External causes are changes in thinking function due to the influence of external forces or diseases. Internal causes are lesions in the cells and tissues responsible for thinking functions and no longer function normally. For example, a company is engaged in business activities and has many links. Problems in one internal link can directly affect the progress of business activities and cause trading losses; external reasons (natural disasters) may also cause losses