Thailand Leying Reproductive Center: How to regulate the endometrium to improve the success rate of IVF?

The uterus is the place where the embryo implants and is also a necessary place for gestation of the fetus. For women, having a thin endometrium is not a good thing. If the endometrium is not in good condition, it will have many effects on the implantation of the fertilized egg and the development of the fetus. So, how should patients with thin endometrium be treated?

What is the reason for the thin endometrium?

I often hear from female friends that the endometrium is thin, menstruation is scant, pregnancy is difficult, or pregnancy is prone to miscarriage, etc. So what does a thin intima mean? In fact, it is thinendometrium, which refers to the abnormal phenomenon that the thickness of the endometrium changes normally with the menstrual cycle. The follicles have matured but the endometrium has not yet reached 10mm.

What is the normal value of endometrial thickness?

1. Proliferative stage

Early stage of proliferation: The endometrium is relatively thin, only about 4-6mm.

Mid-proliferation stage: The endometrium begins to grow, and the thickness of the thick membrane gradually becomes thicker and grows to 8-10mm.

Late stage of hyperplasia: The endometrium adjusts and the thickness of the endometrium widens to 9-10mm.

2. Secretory phase

Early secretory phase: Due to the action of progesterone, the endometrial glands of the endometrium become longer, the thickness of the endometrium is affected, and sugar appears. Original vesicle.

Mid-secretory phase: The endometrium grows, becomes jagged, and remains unchanged in thickness.

Late secretory stage: The endometrium thickens and appears sponge-like. At this time, the thickness of the endometrium is about 5-6mm.

3. Menstrual period

The menstrual period is an important physiological period for women. At this time, women’s estrogen and progesterone will decrease, and the endometrium will gradually return to calmness and begin to Growth and adjustment, the thickness of the endometrium can reach 8-10mm at this time.

What are the causes of thin uterine wall?

1. Endocrine disorders. The thin endometrium of many women is caused by severe endocrine disorders leading to hormonal imbalances in the body, resulting in disordered cyclic changes in the endometrium.

2. Abnormal uterine development is also a reason for the thinning of the endometrium. However, it has been ignored by people for a long time. Clinically, the hysterogram of some patients is no longer inverted pear shape, or even elongated.

3. The age factor not only affects egg quality, but is also an important independent factor affecting the thinness of the endometrium during the IVF cycle. The study found that during the IVF cycle, the average endometrial thickness of patients in the age group <26 years old was 11.9±2.5mm, while the average endometrial thickness of the group >40 years old was relatively thin (9.6±2.4mm), and was found in the group >35 years old. The clinical pregnancy rate increases with endometrial thickening, but there is no such correlation in the <35-year-old group, so the concept of "endometrium age" (ageoftheendometrium) is emphasized.

4. Abortion and curettage can cause endometrial damage and genital tuberculosis. Abortion and curettage can make the endometrium thin. Repeated medical abortion or excessive artificial abortion may cause the endometrium to be thin. Some patients have never had menstruation after abortion, which shows that the abortion seriously damaged the endometrium. If the underlying endometrium is damaged, the consequences can be serious. In addition, endometrial tuberculosis causes damage to the endometrium and causes endometrial fibrous scarring and repair disorders, which affects pregnancy and is also a common clinical cause of thin endometrium.

What are the methods to regulate endometrium thinness?

1. For thin endometrium - Western medicine treatment

a. Estrogen drugs. Estrogen is the first choice treatment for patients with thin endometrium. Estrogen can promote the repair and thickening of the endometrium, which may improve the receptivity of the endometrium and increase the pregnancy rate. Currently, the commonly used ones are oral progesterone, transdermal estrogen patch (Songqi) and *** placed femton (red tablet) to promote endometrial growth.

b. Growth hormone (GH). GH can promote the development of the endometrium, increase the thickness of the endometrium, improve the morphology and blood flow of the endometrium, thereby increasing the receptivity of the endometrium and increasing the pregnancy rate.

c. Gonadotropin-releasing hormone agonist (GnRHa). There are GnRH receptors on the human endometrium, which can directly act on the endometrium to promote endometrial proliferation and thereby improve implantation and pregnancy rates. Foreign literature reports that subcutaneous injection of 0.1 mg of the GnRH-a drug Dabujia can be done on the day of egg retrieval, the day of transplantation, and the third day after transplantation, which can increase the thickness of the endometrium and improve the implantation rate and pregnancy rate.

d. Human chorionic gonadotropin (hCG). Subcutaneous injection of hCG150IU starting on the 8th or 9th day of estrogen supplementation for 7 consecutive days can not only increase the thickness of the endometrium, but also ultimately improve its receptivity.

e. Theobromine caproate combined with vitamin E. Theobromine caproate can dilate capillaries, reduce blood viscosity, and increase tissue oxygen partial pressure. Vitamin E is an antioxidant and can inhibit platelet aggregation. The combined use of the two can increase the thickness of the endometrium in patients with thin endometrium, enhance ovarian function, and significantly increase pregnancy and delivery rates.

f. Sildenafil (Viagra). It can act on the smooth muscle of the uterine artery, increase the blood flow of the uterine artery, improve the development of the endometrium, increase the thickness of the endometrium, and increase the implantation rate and pregnancy rate. Sildenafil administered intrauterineally has a more pronounced effect on the endometrium than oral administration.

2. Diet therapy for thin endometrium

The common cause of thin endometrium is insufficient estrogen. You can eat more foods that supplement estrogen, such as soy products, but you need Pointing out that its biological activity is low, some patients use soy milk instead of drinking water, which is very unscientific. Drinking too much soy milk can cause indigestion, bloating, etc.

In addition, you can also eat more cereals, potatoes, mutton, black-bone chicken and other meats. It is also recommended to eat high-protein foods, such as eggs, chicken, etc. Dried fruits are not taboo and can be eaten at any time. Those with low qi and blood are more effective in replenishing qi and nourishing blood. Walnuts warm yang, and jujube and longan can replenish qi and nourish blood.

Eat less fat, greasy, and stagnant food. Snails, clams, crabs, and turtles tend to be cold foods and should be eaten in small amounts. Among vegetables, rapeseed, kelp, cucumber, shepherd's purse, amaranth, eggplant, leek, loofah, winter melon, bamboo shoots, and lotus root are all cool in nature. It is better to eat less before and after menstruation, and not raw. Fruits are mostly eaten raw, and patients with thin endometrium should also avoid them before and after menstruation.

Eating more apples can improve memory, improve immunity, etc. However, some people say that apples reduce the endometrium and are "endometrial killers" and should never be eaten. There is no report that eating apples has yet been seen. Will reduce the endometrium.

Finally, Thailand LAVIDA Reproductive Center warmly reminds: patients should maintain a good temperament. Mood sometimes has a huge impact on physical health. Being in a bad mood for a long time will affect endocrine function and is also detrimental to the growth of the endometrium.