Cold and bloody.

For a time, the supply of human albumin in China was very tight, and sometimes family members even needed to go to other hospitals or even other places to buy it. One day, the patient's family bought human albumin from other places, but during the transportation, the family froze the albumin, so many people questioned whether such albumin could be used after thawing.

Bopai's point of view is that albumin is a component of plasma, which can be preserved by freezing. Albumin should be preserved, and albumin itself will undergo a temperature change process of MINUS 30 degrees to 60 degrees during the preparation process.

The "fanatical" view is that if albumin freezes, carefully check whether the bottle is broken, and if it is broken, don't use it; If it is intact, the gradient thawing method should be followed, and the temperature should be increased by 3 ~ 5 degrees each time until it is completely thawed. Do not shake after thawing, and check whether there is turbidity and precipitation according to the requirements of light inspection. If this is not the case, you can use. However, it is necessary to closely observe and strictly control the dripping speed.

No matter whether the two views are right or wrong, let's first understand the composition of human albumin, which is a natural blood product commonly used in clinic. The products manufactured and verified according to the standard of China Biological Products Regulations are made from the plasma or serum of healthy people immunized with hepatitis B vaccine, separated and purified by low-temperature ethanol method, and inactivated by heating at 60℃ 10 hour. Albumin content is above 96%, it contains suitable stabilizer, does not contain preservatives and antibiotics, and is used for intravenous infusion.

How to preserve human albumin?

Human albumin must be stored away from light, and the temperature must not exceed 25℃. Freezing is not allowed. This product can be used directly by intravenous infusion. If a large dose of infusion is used, the product must be reheated to the temperature of human body or room before use. Do not use it when the solution is turbid or precipitated, indicating that the protein in the solution is unstable or the solution has been polluted. Once opened, the container must be used immediately. Unused products must be destroyed according to the corresponding requirements.

How long is the shelf life?

At present, most human albumin instructions indicate that the storage condition is 2 ~ 8 degrees (with the development of technology, many albumin now support the storage environment of 2 ~ 25 degrees), and the validity period is 5 years. Generally speaking, albumin is easy to freeze when stored below 0℃. If it was opened after adjusting the temperature, it is estimated that it was thawed at that time. Because of its great effect on human body, once the structure is destroyed, its function will be lost, so it is recommended to abandon it.