Mobile phone game capable of detecting the risk of Alzheimer's disease

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According to a new study by the University of East Anglia, a specially designed mobile game can detect patients with Alzheimer's disease.

The researchers studied the game data of an application called Sea Hero Quest, which has been downloaded and played by more than 4.3 million people around the world.

Glitchers is a game developed by Deutsche Telekom in cooperation with the British company for Alzheimer's disease research in Germany, University College London, University of East Anglia and game developers. It aims to help researchers better understand dementia by understanding the relationship between brains. Space navigation.

As players cross the maze of islands and icebergs, the research team can convert the game process every 0.5 seconds into scientific data.

The research team studied how people with genetic predisposition to Alzheimer's disease play games and compared them with people without Alzheimer's disease.

The research results published in PNAS magazine show that people who are genetically at risk of developing Alzheimer's disease can be distinguished from those who are not at a specific level.

This finding is particularly important because standard memory and thinking tests cannot distinguish between risk groups and non-risk groups.

Professor Michael Hornberger, the lead researcher of UEA Norich Medical College, said: By 2050, dementia will affect 654.38+35 billion people worldwide. We need to find patients early to reduce their risk of dementia in the future.

At present, the diagnosis of dementia is mainly based on memory symptoms, but we now know that this disease will only appear when the condition is very serious. On the contrary, more and more evidence shows that subtle spatial navigation and consciousness defects may be many years earlier than memory symptoms.

Our current findings show that we can reliably detect subtle navigation changes in the genetic risk of healthy people with Alzheimer's disease without any problem symptoms or discomfort. Our findings will provide information for future diagnosis and treatment to solve this devastating disease.

The data collected by the Sea Hero Quest application is very important for research-because every 2 minutes spent playing games is equivalent to 5 hours of laboratory research. There are 3 million players in the world, which is equivalent to 1 700 years of laboratory research.

The team studied the match data of 27 108 British players aged 50-75, which is the most vulnerable age group to develop Alzheimer's disease in the next decade.

They compared the benchmark data with the team that conducted genetic tests in a smaller laboratory.

In the smaller laboratory group, 365,438+0 volunteers carried the APOE4 gene associated with Alzheimer's disease, while 29 volunteers did not. The age, sex, education level and nationality of the two laboratory groups were matched with the baseline cohort.

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