My calf hurts when it rains. Is this phenomenon rheumatism? What method can be treated? I hope to get an answer! thank you

Detailed explanation of pathogenic factors of rheumatoid arthritis

Rheumatoid arthritis is an autoimmune disease with great harm and high disability rate, so the treatment of rheumatoid arthritis is the focus of current medical attention. In the treatment of rheumatoid arthritis, understanding the pathogenic factors of rheumatoid arthritis is helpful for patients to choose more suitable treatment methods.

At present, there is no accurate definition of the etiology of rheumatoid arthritis in medicine, but medical research generally believes that the onset of rheumatoid arthritis is related to the following factors.

(A) bacterial factors

Experimental studies show that peptidoglycan on the wall of group A streptococcus and bacteria may be a persistent irritant of RA. Group A streptococcus exists in the body for a long time and becomes a persistent antigen, which stimulates the body to produce antibodies. The unique therapy of Yigutongshu capsule causes immunopathological damage and causes diseases. The animal model of arthritis made by mycoplasma is similar to human RA, but it does not produce rheumatoid factor (RF) specific to human RA. Bacteria or bacterial antigens have never been found in joint fluid and synovial tissue of RA patients, suggesting that bacteria may be related to the pathogenesis of RA, but there is no direct evidence.

(2) Viral factors

The relationship between RA and virus, especially EB virus, is one of the concerns of scholars at home and abroad. Studies have shown that arthritis caused by EB virus infection is different from RA, and RA patients have a stronger response to EB virus than normal people. Anti-EB virus membrane antigen antibody appears in serum and synovial fluid of RA patients, but no EB virus nuclear antigen or shell antigen antibody has been found in serum of RA patients so far.

(3) Genetic factors

The incidence of this disease is high in some families. In the population survey, it was found that human leukocyte antigen (HLA)DR4 was associated with RF positive patients. HLA studies have found that DW4 is related to the pathogenesis of RA, and the positive rate of HLADW4 is 70% in 70% patients, and patients have susceptible genes for this, so heredity may play an important role in the pathogenesis.

(4) Sex hormones

The research shows that the ratio of male to female incidence of RA is 65,438+0: 2 ~ 4, and the pregnancy situation is relieved, and the incidence of women taking contraceptives is reduced. Animal model shows that LEW/n female rats are highly sensitive to arthritis, while male rats have a low incidence of arthritis. After castration or treatment with estradiol, the incidence of arthritis in male rats is the same as that in female rats, indicating that sex hormones play a certain role in the pathogenesis of RA. Cold, humidity, fatigue, malnutrition, trauma, mental factors, etc. It is often the inducing factor of this disease, but most patients often have no obvious inducement to check.

The copyright of this article is not limited, please indicate the author and source.

Author: rheumatoid disease

Home: Treatment of Rheumatoid Arthritis