Why does activating guanosine cyclase (cGMP) increase the content of cGMP in vascular smooth muscle cells and relax the smooth muscle? Find the mechanism of action

The mechanism is that when sodium nitroprusside comes into contact with vascular endothelial cells and red blood cells, its molecules release NO, activate guanylate cyclase in vascular smooth muscle cells and platelets, increase CGMP formation, and lead to vascular smooth muscle relaxation.

It is cold in winter, when people breathe, their teeth will come into indirect contact with cold air, which is easy to cause periodontitis, gum bleeding and other diseases. Especially in the case of alternating hot and cold, the incidence of toothache will be greatly improved. Nobel dentist

Therefore, in case of sudden temperature drop or windy weather, you should wear a mask when going out, strengthen your awareness of protection, and avoid catching a cold and losing your teeth. When you enter the room from the cold outdoor, you should have a rest, drink some hot water, and then eat hot food to avoid the stimulation of alternating cold and hot. Try to use warm water when gargling at ordinary times to avoid the stimulation of cold water on teeth. Nobel dentist