Gout patients taking these drugs may induce gout attacks, so we must pay attention to them.

There are more and more young people with gout. The main reason is that they eat too much wine, seafood and animal offal. Delicious food and wine glasses every day make it known as "the emperor's disease", while gout, a common disease among middle-aged and elderly men, has a trend of rejuvenation in recent years. Young male patients are still in the majority, and the bigger the body, the higher the incidence. It is reported that the youngest gout patient in the world is only twelve or thirteen years old, which is surprising. Gout is a senile disease. Gout is a pathological change caused by high uric acid concentration in blood. It is an arthritis disease with sudden onset and easy recurrence, accompanied by severe pain. Professor Jasmine Yi Dong, Chairman of the Rheumatology Society of China and Chief Physician of Rheumatology Department of Union Medical College Hospital, said in an interview that gout used to occur most often in middle-aged and elderly men, because it usually takes several years from high uric acid to symptoms, and there is a process from quantitative change to qualitative change. But in recent years, clinical observation shows that there are more and more young patients, which has a lot to do with the current diet structure. Under normal circumstances, uric acid is a by-product of cell metabolism. Some foods (such as seafood, wine, animal liver, brain, heart, etc. ) Purine, a precursor rich in uric acid, will appear in normal people's blood. With the increase of age, the uricase metabolizing purine in middle-aged and elderly people is less and less, and the content of purine in blood is increased, which is easy to cause gout. From this perspective, gout should be said to be a disease of middle-aged and elderly people. Actually, it is not. More and more young people have joined the gout team because of their hobbies of "seafood" and alcohol and tobacco. Why? Professor Dong said that although young people's physiological functions are very active and there are enough uric acid decomposing enzymes in their bodies, they still "block" daily seafood and raise glasses frequently, because enzymes are not enough to compensate for excessive intake of purine, which leads to abnormal increase of uric acid level in blood and gout. Just like obesity, which used to exist only among middle-aged and elderly people, young people and even children are now more than the elderly. The intake of "three highs" is too much to compensate, and it will make people fat if they accumulate in the body. Of course, the cause of gout is far more than diet. Work stress, emotional tension, fatigue, irregular life and organ dysfunction can all be induced. Gout comes and goes in a hurry, lingering. If you don't want gout, people who like seafood, animal offal and good wine should close the entrance. Otherwise, gout may find you one day. This is not sensational. Once the uric acid content in your body reaches a certain level, gout will "come unexpectedly" and will never get rid of it, eventually leading to joint deformity. Professor Jasmine Yi Dong said that the most typical first symptom of gout is sudden joint pain in the big foot, which also affects the arch, ankle, knee, wrist and elbow. Because the blood circulation of joints is generally poor, uric acid is easy to crystallize and deposit around joints. Arthralgia with gout as the first symptom will last for 7- 10 days. Even without treatment, the pain will gradually disappear and the joint function will return to normal. But it is likely to recur, and there are generally no symptoms before the next gout attack. Recurrent gout can lead to permanent joint injury and joint deformity. If gout occurs before the age of 30, gout generally tends to get worse. Therefore, experts remind that no matter how old you are, as long as joint pain suddenly occurs and lasts for several days, you should go to a big hospital with rheumatology to check whether uric acid in the blood exceeds the standard to confirm whether gout is true. Once gout is diagnosed, it should be treated actively. According to reports, drugs such as indomethacin and ibuprofen on the market can effectively relieve swelling and pain, and at the same time, they should cooperate with purinol to help purine excretion and block the formation of uric acid in the body. Never be superstitious about the "doctor" on the telephone pole. At the same time, patients should drink more water, ban alcohol and alcoholic beverages, and eat less seafood and animal offal. If you control your weight and lose weight successfully, the high uric acid in your blood will automatically approach the normal level, and actively preventing gout recurrence is the best policy. Four dangerous complications of gout Patients with gout will obviously reduce the metabolic function of sugar and fat in the body, so it is quite easy to be complicated with various serious diseases: diabetes and gout are diseases caused by abnormal metabolism in the body, which are easy to be complicated with patients. Diabetes is due to the lack of insulin hormone that regulates blood sugar, which leads to persistent hyperglycemia in the body; There is a great correlation between uric acid value and blood sugar value. Usually, people with high uric acid levels have higher blood sugar levels. Most patients with hypertension/hyperlipidemia and gout are obese, and excessive fat accumulation in the body can easily harden the arteries and cause hypertension; Moreover, because gout patients tend to eat high-fat and high-calorie foods in their daily diet, the content of neutral fat in the body is quite high, and the cholesterol value usually exceeds the normal standard, so they are one of the people prone to hyperlipidemia. Patients with myocardial infarction/angina pectoris are prone to arteriosclerosis, which leads to insufficient blood supply to the heart and poor blood circulation, and the probability of angina pectoris or myocardial infarction is particularly high, especially in patients with gout complicated with hyperlipidemia. Cerebrovascular disorders are also caused by arteriosclerosis, and the difference is in the brain. Its symptoms include headache, dizziness, numbness or paralysis of hands and feet. In severe cases, the patient may lose consciousness or even die. In addition to angiography, the patient needs to have a CT and MRI examination of his brain. Gout is a hyperuricemic disease caused by purine metabolic disorder, which is characterized by recurrent acute arthritis, gout nodules, gouty nephropathy and uric acid kidney calculi. How can gout patients eat to be healthy? The incidence of gout and hyperuricemia is closely related to physical and genetic factors, but the environment and lifestyle will also have great influence. When gout attacks, besides treatment, we should also pay attention to the improvement of diet and life: the diet that reduces uric acid value should avoid foods containing purine and avoid contributing to high uric acid, such as fish, viscera, gravy, soybeans, shrimp and shellfish. In addition, the urine of patients with hyperuricemia is mostly alkaline, and acidic urine is the cause of urinary calculi, so we should also pay attention to foods that are easy to alkalize blood. Avoid overeating. Excessive calorie intake will lead to obesity, and food contains purine, which will directly lead to an increase in uric acid. Be careful not to overeat; In order to control intake and give consideration to satiety, we should eat more seaweed, mushrooms and konjac foods rich in dietary fiber and low in calories. It is forbidden not to eat or eat too fast, and it is not appropriate to control weight through diet, so as to avoid the decomposition of cells and the release of uric acid due to fasting; In addition, irregular eating habits will lead to obesity and have a negative impact on gout. For example, if you don't eat breakfast, long-term fasting will make people eat heartily at lunch; If you eat after a hungry meal, your body will absorb more calories and quickly store them as fat. In addition, if you eat too fast, it will easily lead to overeating and obesity. Pay attention to balanced nutrition. If you don't eat food containing purine at all, it is difficult to maintain a nutritional balance. Therefore, when eating, we must pay attention to the intake of different ingredients to maintain a balanced nutrition. Replenishing water can reduce the concentration of blood and urine, produce a lot of urine, help uric acid excretion and avoid kidney calculi caused by gout; In addition, acidic urine tends to be alkaline after being replenished with water. How to use drugs for gout The incidence of gouty arthritis is increasing year by year, and doctors and patients have greatly improved their understanding of the disease. However, there are still some noticeable problems in drug treatment. First of all, many patients are treated with a lot of antibiotics, especially penicillin. This may be a wrong diagnosis of erysipelas and other bacterial infections, or a misunderstanding in treatment. Second, the principle of medication in acute attack and remission is different. As we all know, acute gout attacks with severe pain. At this time, the treatment should be mainly anti-inflammatory and analgesic, and non-steroidal anti-inflammatory drugs such as croftin and diclofenac are necessary choices. Hormones are sometimes used, especially in cases of severe pain and poor response to non-steroidal anti-inflammatory drugs. However, due to its serious side effects, it is not recommended in clinic. The remission of acute gouty arthritis does not mean the cure of the disease. Follow-up treatment should be more important. Thirdly, the choice of drugs affecting purine metabolism should be individualized as much as possible according to different metabolic characteristics. In the course of treatment, we should try to keep the blood uric acid at a low level for a long time (such as more than 3 months), which is conducive to reducing the damage of uric acid to various tissues and organs and relaxing our daily diet in the future. What are the "culprits" leading to gouty arthritis? Research shows that fatigue, irregular diet, excessive drinking, cold, joint trauma and excessive exercise are in turn. Therefore, to stay away from gout, the key is to pay attention to rest and adjust diet. For workaholics, when work threatens their health, they must push away some unnecessary entertainment and even work, keep their rest time for themselves, pay attention to the combination of work and rest, and avoid overwork. Patients with acute gout attack should take indomethacin or colchicine under the guidance of a doctor, which can quickly control the swelling and pain of gouty arthritis. The earlier you take the medicine, the better the effect. Colchicine acts quickly, but it can cause nausea, vomiting, diarrhea, leukopenia and other adverse reactions, so it should be used under the guidance of a doctor. Indomethacin is not as effective as colchicine, but it also has good anti-inflammatory and analgesic effects. Decrease the amount after the symptoms are relieved, and stop taking the medicine after the symptoms disappear. In remission stage, because the patient's blood uric acid is high or normal, drugs that inhibit uric acid synthesis can be used for a long time. Commonly used drugs include allopurinol, gout elixir and probenecid. It can control hyperuricemia and prevent gout recurrence. Taking the above drugs requires regular review of liver function and white blood cell count. In addition, the following groups of people should have regular physical examinations and pay close attention to blood uric acid concentration: the elderly over 60 years old; Obese middle-aged men and postmenopausal women; Patients with hypertension, arteriosclerosis, coronary heart disease and cerebrovascular disease; Diabetic patients (mainly type II diabetes); Arthritis of unknown causes, especially in patients over middle age; Kidney calculi, especially patients with multiple kidney calculi and bilateral kidney calculi; Members with a family history of gout; Middle-aged people who have long been addicted to meat and have drinking habits. When gouty arthritis is suspected, further X-ray examination of bone and joint should be carried out to confirm the diagnosis. "Eight Preventions" 1 for gout patients. Preventing obesity is not only a risk factor for gout, but also a promoting factor for the development of gout. The serum uric acid level of obese people is usually higher than that of normal people. If gout is accompanied by obesity, it will also affect the efficacy and reduce the drug sensitivity. Therefore, obese people want to lose weight, the main measures are to control the total calories, limit fat intake, and insist on participating in physical exercise. Pay attention to losing weight, because if fat and other tissues decompose too fast, the concentration of ketone bodies and lactic acid increases, and uric acid secretion is inhibited, it will induce an acute attack of gout. It is generally advisable to lose about 2 kg in 2 ~ 3 weeks. 2. Preventing hypercoagulability of hyperlipidemia blood can promote the occurrence and development of atherosclerosis, and hyperlipidemia is often accompanied by obesity and hyperuricemia. Therefore, hyperlipidemia not only constitutes a risk factor for gout, but also increases cardiovascular complications of gout patients and reduces their quality of life. Therefore, patients with gout should measure their blood lipids regularly. If the blood lipid concentration is high, first of all, it is necessary to control the diet, eat less low-fat foods and avoid high-fat foods, and take lipid-lowering drugs when necessary to restore blood lipid to normal, reduce cardiovascular complications and prevent gout attacks. Third, anti-hyperuricemic food is the source of uric acid production. If you eat food with high purine content, it is easy to induce hyperuricemia and gout attack. At present, the foods with high purine content are mainly animal viscera such as liver, kidney, heart and pancreas, fish such as sardines, anchovies, cod, salmon and their eggs, and animal meat such as salted pork, leg of lamb, grouse, pheasant and pigeon. Gout patients should eat less or not eat the above foods. They can choose fresh pork, beef, chicken, freshwater fish and shrimp to supplement a certain amount of protein. They can also eat bean products and dried fruits, and eat more fresh vegetables to make their diet more reasonable and help prevent gout attacks. Fourth, preventing alcoholism and drinking alcohol is one of the most important reasons for gout attacks. This is because ethanol, the main component of alcohol, can increase lactic acid in the body, and lactic acid can inhibit the excretion of uric acid by renal tubules; Ethanol can also promote purine decomposition and directly increase blood uric acid; At the same time, alcohol itself can provide purine raw materials, for example, beer contains a lot of purine components. Therefore, heavy drinking can cause gout attacks, and long-term chronic drinking can cause hyperuricemia. Gout patients had better stop drinking. If they can't stop drinking for a while, they should also pay attention to avoid drinking a lot and avoid drinking too much. 5. Preventing the increase of lactic acid production in the body after strenuous exercise can inhibit the excretion of uric acid by renal tubules and increase blood acid. Strenuous exercise can also cause excessive sweating, dehydration of the body, decrease blood volume and renal blood flow, affect uric acid excretion, and cause transient hyperuricemia. Therefore, gout patients should not exercise vigorously. Exercise should choose less intense aerobic exercise, such as walking, walking, cycling, swimming, etc. At the same time, avoid high-intensity sports, such as ball games, mountain climbing and jumping. And pay attention to rest and drink plenty of water during exercise. 6. Prevent colds and overwork. Both cold and overwork can make the autonomic nervous regulation function of human body disorder, which is easy to cause the contraction of body surface and visceral blood vessels, including renal blood vessels, thus causing the reduction of uric acid excretion. Therefore, gout patients should wear warm clothes in the cold season to avoid catching a cold. Work and rest should be combined in daily life to avoid overwork and mental stress. Developing good living habits can greatly reduce the incidence of gout. Seven. The incidence of kidney calculi in patients with gout prevention in kidney calculi is high, which is mainly related to the increase of uric acid excretion, that is, the higher the concentration of uric acid, the higher the incidence of kidney calculi. Therefore, in order to promote uric acid excretion and prevent urinary calculi, it is necessary to drink more water, and the daily drinking amount is more than 2000ml. Pay attention to alkaline urine at the same time. In 0.cn, you can take sodium bicarbonate orally every day at QQ: 328426390.